Patient Instructions for Transdermal Pain Creams

This prescription includes one or more of the following medications:

  • Ketoprofen – Anti-inflammatory (NSAID)
  • Lidocaine – Anesthetic
  • Baclofen – Muscle Relaxant
  • Gabapentin – Nerve Pain
  • Amitriptyline – Nerve Pain
  • Clonidine – Nerve Pain
  • Acyclovir – Antiviral
  • Ketamine – Anesthetic

Rationale for Using Topical Medications

Capsules and tablets taken orally must pass through a patient’s digestive tract before making their way into the system.  For anti-inflammatory, muscle relaxants, and other medications, this can result in lessened potency and some gastrointestinal side effects.  By treating the pain at its trigger point, relief and recovery may be strengthened.

Side Effects

Skin rash or irritation at the site of application.  Consult with our pharmacist about any side effect or questions at (813) 948-4321


Do not use this medication if you have an allergy to any of the medications listed.  Ketoprofen may cause sun sensitivity, therefore, stay out of the sun when using this medication.

How to Use this Medication

  1. You may apply heat (for example, a warm washcloth or heating pad) to the area(s) before applying the cream. This increases blood circulation to the area.  Application after a shower or bath will also accomplish this result.
  2. Apply the cream sparingly to the affected area(s) and rub in well. Wash hands well.
  3. Repeat steps 1 & 2, two to three times a day as needed unless otherwise instructed. For the best results, one application should be done at bedtime.
  4. In the unlikely event that you develop a rash from using the gel, discontinue its use. The rash should disappear shortly after.  If you need something to help control any itching that might occur, call one of our pharmacists at (813) 948-4321.