Rx Express Compounding Pharmacy is a trusted pharmacy in Lutz, Florida, serving hundreds of customers each week with personalized care. With over two decades of experience, we specialize in custom compounded medications.
The pharmacy features an open, transparent workspace and a friendly team committed to quality and service. Whether visiting in person or using our convenient online services, experience the professionalism of a busy, community-focused pharmacy.
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Compounding for Lutz, Wesley Chapel, Land 'O Lakes, Tampa, & Florida for 23 years.
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Professional Compounding Centers of America
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Doctor review/assessment – Pharmacy will call you to discuss.
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Receive your Semaglutide with Free Shipping anywhere in Florida.
- SemaStart - $289 per month
- SemaFlow - $359 per month
- SemaMax - $449 per month
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Free Shipping
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Daily Dose & Easily Adjustable
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Compliant & No Supply Issues
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No Shots. No Needles. No Fridge.
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Smoother Drug Conc. Curves*
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Drug Delivery Study**
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Questions
Compounded Semaglutide Oral Suspension for Sublingual Administration
Semaglutide is a game-changer for people who have high blood pressure, diabetes, or high cholesterol due to being overweight. In just the past few years, semaglutide has helped countless people with diabetes achieve healthy blood sugar levels. More recently, it has helped people lose weight without invasive surgery.
Page Navigation Links
- What is Semaglutide?
- How Semaglutide Works?
- GLP-1 Receptor Agonist Discussion
- Peaks and Troughs
- What is Sublingual Semaglutide and How is it Different?
- What is the Dosage and How is it Supplied?
- How much does it Cost?
- How do I Get (or prescribe) Sublingual Semaglutide?
- Additional Links and White Papers
- What are the Side Effects?
- Is Sublingual Semaglutide Approved by the FDA?
What Is Semaglutide?
Semaglutide is an agonist, which means it mimics the action of a naturally-occurring hormone. This hormone, known as GLP-1, plays a role in regulating blood sugar, appetite, and digestion. More specifically, the GLP-1 hormone reduces appetite and increases insulin to reduce blood sugar. As an agonist, semaglutide triggers the same actions to lower blood sugar and decrease appetite.
How Semaglutide Works
Semaglutide works by affecting specific hormones produced by the pancreas. These hormones send signals about feeling of hunger and satisfaction to the brain. More specifically, the hormones latch onto receptors found in the brain, pancreas, and other areas of the body – binding to these receptors causes changes in the body that reduce appetite and more.
GLP-1 Receptor Agonists
Semaglutide belongs to the class of drugs known as glucagon-like peptide-1 (GLP-1) receptor agonists. The use of these drugs has grown substantially worldwide.
This class includes several different injectable medications administered through a needle, and as a tablet that the patient takes by mouth. There are drawbacks to these injectables and tablets, though. Many patients would prefer to avoid injections, for example, and the digestive tract does not absorb the medication well from the tablets.
Because of these disadvantages and for other reasons, prescribers and patients may prefer a patent-pending compounded formulation of semaglutide.
Peaks and Troughs
Normally administered through an injection or pill, semaglutide levels can have peaks and troughs, or very high levels immediately after administration and very low levels just before the next dosage. It can also take several weeks for the medicine to reach a steady state, in which the peaks and troughs normalize to create a therapeutic level that does not fluctuate.
The peaks and troughs also make it difficult to titrate, or increase/decrease, the dosages. When patients start taking semaglutide, they usually start on a lower dosage to avoid stomach upset. The doctor may increase the dosage after 4 weeks and adjust the dosage every 4 weeks.
Taking small dosages more often, such as once a day instead of once a week, can reduce the difference between peak and trough drug levels compared to a once-a-week dosage. Decreasing the highs and lows of peak and trough drug levels can help smooth out dosage adjustments. It also helps balance steady-state concentration, which is the amount of drug leaving the body with the amount of semaglutide entering the body. Compounded semaglutide oral liquid for administration under the tongue A recent study showed that our compounding base can deliver semaglutide into and through the gums and other oral tissues.
What Is Sublingual Semaglutide And How Is It Different?
Sublingual (SL) semaglutide is a compounded suspension of semaglutide taken sublingually, or under the tongue. We designed our patent-pending formulation with a special base capable of carrying large molecules, like those that make up semaglutide, through the oral tissues of the mouth. This compounding base is self-emulsifying, which means it suspends beads of the active ingredient in liquid. The base also has special properties that help hold it onto mucosal tissue long enough to be absorbed completely and then pass easily through oral tissues into the body.
A recent in vitro study demonstrated the ability of our compounding base to deliver semaglutide into and through human gingival and oral tissues.
What Is The Dosage And How Is It Supplied?
An important consideration when titrating the dosage is that semaglutide has a half-life of approximately 7 days, which means half of the medicine has left the body by the time the patient receives another dosage. This half-life affects how quickly the patient will reach steady state – with semaglutide, it will usually take 4-5 weeks to reach steady state drug concentrations. Also, since the dosages are daily instead of weekly, patients may experience a smoother titration and reach steady state concentration faster.
When adjusting the dosage, it's important to note that semaglutide stays in the body for about 7 days and usually takes 4-5 weeks to reach steady drug levels. With daily dosages instead of weekly ones, patients may find it easier to adjust gradually and reach steady levels smoothly.
The starting dosage for semaglutide is usually 0.25 mg injected beneath the skin once a week for four weeks. This lower dosage helps build levels of semaglutide and helps patients reach a steady state. Doctors then typically increase the dosage every 4 weeks, with a typical maximum dosage of 2.4 mg once a week. Following each dosage change, it can take as long as 4 to 5 weeks to reach steady state.
In sublingual form, Semaglutide comes in an amber bottle along with a 1 ml dropper for easy under-the-tongue administration. This drug needs to be stored at room temperature, and shaken thoroughly before each use. The patient should apply the dosage under the tongue and hold it for at least 5 minutes before swallowing, and avoid eating or drinking anything for at least 30 minutes.
Providers: An important consideration when titrating the dose is that semaglutide has a half-life of approximately 7 days and will usually take 4-5 weeks to reach steady state drug concentrations. Also, since the doses are daily instead of weekly, patients may experience a smoother titration and smoother steady state concentration. Patients: If you are starting semaglutide for the first time, you may be instructed to begin with a titration as directed by your provider. This means that you will start with a smaller dose and increase over time. Titrating this medication can help reduce gastrointestinal side effects and nausea. After a dosage increase it can take up to 4-5 weeks to reach maximum medication levels for that dose.
The medication comes in an amber bottle with a 1ml dropper for easy under-the-tongue administration. It should be stored at room temperature and shaken before use. The dose determined by your doctor should be applied under your tongue for at least 5 minutes and then swallowed. Avoid eating or drinking anything for at least 30 minutes after administration.
How Much Does It Cost?
- SemaStart - $289 per month
- SemaFlow - $359 per month
- SemaMax - $449 per month
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Free Shipping
How Do I Get (Or Prescribe) Sublingual Semaglutide?
Doctors and other providers can send in prescriptions for sublingual semaglutide by:
- Faxing prescriptions to 813-948-1889 (see the below fax order form)
- Phoning in prescriptions to 813-948-4321
- E-scribed prescriptions to Rx Express Compounding Pharmacy by (1) selecting Compounded medication or Compounding something similar and (2) type the following into the sig field: semaglutide 1mg/dose OR 2mg/dose OR 3mg/dose. One dose daily, One month supply.
For patients: Sublingual Semaglutide is available with a valid prescription from your healthcare provider. Once we have a prescription, we will reach out to you with more details.
We created a prescription order form (see below) that you may print and bring to your appointment to discuss this medication with your provider. (The second page of this document will provide more information for your provider) Our Fax # is 813-948-1889.
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Get Your Prescription
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Fax Order Form
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Prescriber Questions
Research:
Researchers are currently conducting a number of studies that are providing a wealth of information about semaglutide in general and the patent-pending sublingual formulation as well. Please check back often, as we will share information about Semaglutide and GLP-1 receptor agonist medications in general.
The most common side effects include gastrointestinal related symptoms such as abdominal pain, constipation, diarrhea, nausea, and vomiting. These side effects may be more common when the patient first starts semaglutide and when titrating to stronger dosages. Extreme sensitivity reactions, such as rash, trouble breathing, swelling of the mouth, face, or throat can occur and will require immediate medical attention. Low blood sugar can occur, especially if taking medication for diabetes. Discontinuing semaglutide may be necessary if these reactions occur.
Is Sublingual Semaglutide Approved by the FDA?
The Food and Drug Administration does not approve compounded drugs, which are custom-made medications made from FDA-approved medications. Because the medications used in the compounded formulation of sublingual semaglutide are already FDA-approved, sublingual semaglutide formulations are not FDA-approved.
Formulas and/or material listed are not to be interpreted as a promise, guarantee or claim of therapeutic efficacy or safety. The information contained herein is not intended to replace or substitute for conventional medical care, or encourage its abandonment. Every patient is unique, and formulas should be adjusted to meet their individual needs.
